House will do whatever it takes to solve a case before it's too late, from sending one of his team to break into a patient's home in search of clues, to attempting a controversial, trial-and-error form of treatment to see how a patient responds. House's methods may be suspect, but his results are not — he saves lives no one else can. Always in House's way is Dr. Lisa Cuddy, the Dean of Medicine and hospital administrator — and ethical gatekeeper of the hospital who is in constant conflict with House over his extreme treatments and unconventional behavior. House's former love Stacy Warner recently accepted a job as General Counsel to the hospital, and her presence there has reignited feelings House thought were safely buried.
Episode 1
When a Death Row inmate mysteriously and suddenly collapses after hallucinating, House jumps at the chance to take the case for its difficulty and because it's "cool."
Episode 2
A girl's unimaginable bravery toward her terminal illness makes House suspicious as he puts a life-or-death decision about her case in her young hands.
Episode 3
Cuddy struggles with a case of guilt when her handyman is injured while at her place, and House and his team have to work fast to save the young man's pursuit of the American Dream.
Episode 4
House's patient is willing to die in order to further his social cause.
Episode 5
Lies between a father and son may prevent House and his team from saving their patient.
Episode 6
House's wheels start turning when a pro-cyclist admits to taking performance-enhancing drugs.
Episode 7
A patient with AIDS stalks House to get him to take his case; House and Stacy stalk a mouse in her attic; and Cameron faces a health scare of her own.
Episode 8
A patient's death prompts an investigation into whether Chase or House may have been responsible for her death.
Episode 9
With Foreman as House's supervisor, the team must figure out if a woman who cried wolf too many times is really ill.
Episode 10
A journalist's head injury results in unintelligible speech, leaving House and his team at a loss; and the heat is turned up between House and Stacy when they're out of town.
Episode 11
While House's staff tries to diagnose a woman whose uncontrollable muscle flailing caused her to crash her car, House and Stacy try to resolve their relationship issues once and for all. Cameron refuses to take her HIV test, wary of the results.
Episode 12
While a severely burned teenager is admitted and his blood tests come back with strange results, House makes himself the guinea pig in his own unofficial tests of a new drug designed to treat migraines to prove a former medical school colleague is wrong about the drug.
Episode 13
House uncovers a startling secret when he treats a teenage supermodel for heroin addiction. Meanwhile, Wilson hopes the increased leg pain in House's leg is an indication his leg nerves are regenerating.
Episode 14
House takes the case of a man who experienced a seizure but wasn't aware it happened. When the man suffers a heart attack and needs a heart transplant, the team races to diagnose a dead woman's illness so they can harvest her heart to save their living patient.
Episode 15
House believes a woman is trying to kill her husband and tries to find the proof to confirm his suspicions. When Wilson moves in with House after separating from his wife, he learns Wilson is a great cook.
Episode 16
A teenage heart transplant patient is rushed to the hospital when she has an allergic reaction while living in a "clean" room, and House and Wilson work out the kinks of their new living arrangement.
Episode 17
When a six-year-old boy is brought in with the same symptoms as another patient who died years ago under House's care, House believes the cases are identical and he can predict the course of the boy's illness. Meanwhile, the clinic hosts a poker night to benefit the oncology department.
Episode 18
House has to work fast when a woman comes in with a life-threatening case of insomnia. Meanwhile Cameron is angry at Foreman for stealing an article she worked on.
Episode 19
House treats a 15 year old faith healer, while Wilson feels left out when he finds out House has a weekly poker game.
Episode 20
When a police officer with a gunshot wound to the head and uncontrollable laughter is admitted, House and the team are baffled. When Foreman begins showing the same symptoms, they race to determine the cause of the illness before Foreman's condition takes the same path.
Episode 21
Foreman continues to experience the same progression of symptoms as the police officer. When he realizes he may be facing imminent death, he calls his father who comes to his son's side. As it comes down to a race against time, House believes the solution to the illness is in the police officer's apartment.
Episode 22
A young mother has a seizure while bathing her newborn son and nearly drowns him. House and the team have two cases at one time as they try to save the infant and determine the cause of the mother's seizures.
Episode 23
A 16-year-old Hurricane Katrina victim suffering from hallucinations as a result of the tragedy is brought to House by his former bandmate who recently found out the girl is his daughter. Although House fears his friend is being scammed, he takes the case. As he works his way through the girl's lies so he can diagnose and treat her, he's forced to tell a few lies of his own.
Episode 24
House is shot by a former patient and must share a recovery room with the gunman.